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Search Results for " airway inflammation "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8747	Levofloxacin hydrochloride		DNA gyrase , Topoisomerase
	Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...		DNA gyrase , Topoisomerase
T6828	ZL0420		Epigenetic Reader Domain
	ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has IC 50 values of 27 nM against BRD4 BD1 and 32 nM against B...		Epigenetic Reader Domain
T60072	ZL0590		Epigenetic Reader Domain
	ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.		Epigenetic Reader Domain
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T1451	Levofloxacin hydrate	Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c...		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T77045	Itepekimab	REGN-3500,SAR-440340	Others
	Itepekimab (REGN-3500) is a potent monoclonal antibody against IL-33.Itepekimab reduces airway inflammation and associated tissue damage in in vivo experiments and can be used to study asthma.		Others
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T10110	3-CPs	3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen	Antibiotic
	3-CPs (3-Carbethoxypsoralen) is a bleomycin-induced serotypic podoplanar polysaccharide in mouse lung fibrosis that belongs to the psoralen family and interferes with antibody-mediated bacterial killing.3-CPs delays bleo...		Antibiotic
T36503	Sodium Hydrogen Sulfide (hydrate)		Others
	Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul...		Others
T28878	Sul-121 HCl	Sul-121 Hydrochloride
	Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati...
T32156	Indimilast
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cel...
T41121	Elubrixin tosylate	SB-656933 tosylate,Elubrixin tosylate
	Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b ...
T76320	FIZZ-1 (32-51) (mouse)
	FIZZ-1 (32-51) (mouse), a cysteine-rich secretory protein, is predominantly expressed in macrophages, bronchial epithelial, and type II alveolar epithelial cells (AEC) during allergic airway inflammation. Additionally, i...
T78371	Ac2-26 ammonium
	Ac2-26 ammonium, an N-terminal peptide of annexin 1, exhibits anti-inflammatory properties, reduces IKKβ protein levels in lysosomes via chaperone-mediated autophagy (CMA), improves lung ischemia-reperfusion injury outco...
TP2008	Lyn peptide inhibitor
	Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinoph...
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) v...
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model o...

Compounds

Levofloxacin hydrochloride

T8747

Synonym:

Target: DNA gyrase, Topoisomerase

ZL0420

T6828

Synonym:

Target: Epigenetic Reader Domain

ZL0590

T60072

Synonym:

Target: Epigenetic Reader Domain

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Levofloxacin hydrate

T1451

Synonym: Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Itepekimab

T77045

Synonym: REGN-3500,SAR-440340

Target: IL Receptor, CXCR

3-CPs

T10110

Synonym: 3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen

Target: Antibiotic

Sodium Hydrogen Sulfide (hydrate)

Synonym: Sul-121 Hydrochloride

Synonym: SB-656933 tosylate,Elubrixin tosylate

Target:

FIZZ-1 (32-51) (mouse)

Lyn peptide inhibitor

Betamethasone 21-phosphate (sodium salt hydrate)

T38100

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T3872	Nodakenin	(+)-Marmesinin	AChE
	Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.		AChE
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T6567	Levofloxacin	Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin	Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.		Topoisomerase , Antibacterial , Antibiotic
T4S2164	Narirutin	Naringenin-7-O-rutinoside,Isonaringin	Others , Antibacterial
	1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum...		Others , Antibacterial
TMA1570	Sappanone A		NF-κB , Nrf2
	Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-induced asthma.		NF-κB , Nrf2
T2978	Mogroside V		AMPK
	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce...		AMPK
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
T40787	Platyconic acid A
	Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation.
TN4819	(-)-Praeruptorin A		ATPase , IL Receptor , Calcium Channel , P-gp
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ...		ATPase , IL Receptor , Calcium Channel , P-gp

天然物製品

Nodakenin

T3872

Synonym: (+)-Marmesinin

Target: NF-κB, Autophagy

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Levofloxacin

T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

Narirutin

T4S2164

Synonym: Naringenin-7-O-rutinoside,Isonaringin

Target: Others, Antibacterial

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-01202	CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated	Human	HEK293 Cells
	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons...
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules ...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid...

CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated

TMPK-01202

Species: Human

Expression System: HEK293 Cells

MRGPRX2 Protein, Human, Recombinant (His)

TMPH-01640

Species: Human

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02526

Species: Mouse

Expression System: E. coli

PLA2G10 Protein, Mouse, Recombinant (His & Myc)

TMPH-02690

Species: Mouse

Expression System: E. coli